Pan-Disease Cytokine Activity Atlas

Interactive exploration of cytokine signaling activities across healthy tissues, cell types, and disease states using single-cell RNA sequencing data.

Atlas Overview

This atlas provides a comprehensive view of cytokine signaling activities computed from single-cell transcriptomic data using CytoSig and SecAct methods.

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CIMA Healthy Donors
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Organs Profiled
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Cell Types
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Inflammation Samples
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CytoSig Signatures
Data Sources
Dataset Description Records

CIMA: Clinical Correlations

Explore correlations between cytokine activities and clinical parameters in 421 healthy donors from the CIMA cohort.

Showing top correlations sorted from high to low.

Age Correlations
Spearman correlation with donor age (sorted high to low)
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BMI Correlations
Spearman correlation with body mass index (sorted high to low)
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Blood Marker Abbreviations (click to expand)
ALB - Albumin (liver function, nutrition)
GLOB - Globulin (immune proteins)
A/G - Albumin/Globulin ratio
TP - Total Protein
ALT - Alanine Aminotransferase (liver enzyme)
AST - Aspartate Aminotransferase (liver/heart enzyme)
AST/ALT - AST to ALT ratio (liver damage pattern)
GGT - Gamma-Glutamyl Transferase (liver/bile duct)
Tbil - Total Bilirubin (liver function)
DBIL - Direct Bilirubin (conjugated)
IBIL - Indirect Bilirubin (unconjugated)
CHOL - Total Cholesterol
HDL-C - HDL Cholesterol ("good" cholesterol)
LDL-C - LDL Cholesterol ("bad" cholesterol)
TG - Triglycerides (blood fat)
GLU - Glucose (blood sugar)
Cr - Creatinine (kidney function)
UR - Urea/BUN (kidney function)
UA - Uric Acid (gout, kidney)
Biochemistry Correlation Heatmap
Spearman correlations between cytokine activities and blood biochemistry parameters
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Volcano Plot: Differential Cytokine Activity
Effect size (log2 fold change) vs significance (-log10 p-value)
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Inflammation Atlas: Disease Signatures

Explore cytokine activity signatures across 66 immune cell types from 817 patient samples spanning multiple inflammatory diseases.

Cell Type Activity Profile
Mean cytokine activity across immune cell populations
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Activity Heatmap
Top variable cell types x cytokines
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scAtlas: Tissue & Cell Type Signatures

Explore cytokine activity signatures across 35 organs and 376 cell types from the Human Cell Atlas.

Select an organ

Click on an organ to view top signatures

Cell Type Activity Heatmap
Mean cytokine activity scores across cell types (top 100 most variable)
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Methods

Cytokine Activity Inference

Cytokine signaling activities were inferred from single-cell RNA-seq data using two complementary approaches:

Statistical Analysis

Correlations were computed using Spearman's rank correlation coefficient. P-values were adjusted for multiple testing using the Benjamini-Hochberg procedure. Differential analysis was performed using the Mann-Whitney U test.

Data Sources