Interactive exploration of cytokine signaling activities across healthy tissues, cell types, and disease states using single-cell RNA sequencing data.
This atlas provides a comprehensive view of cytokine signaling activities computed from single-cell transcriptomic data using CytoSig and SecAct methods.
| Dataset | Description | Records |
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Explore correlations between cytokine activities and clinical parameters in 421 healthy donors from the CIMA cohort.
Showing top correlations sorted from high to low.
Explore cytokine activity signatures across 66 immune cell types from 817 patient samples spanning multiple inflammatory diseases.
Explore cytokine activity signatures across 35 organs and 376 cell types from the Human Cell Atlas.
Click on an organ to view top signatures
Cytokine signaling activities were inferred from single-cell RNA-seq data using two complementary approaches:
Correlations were computed using Spearman's rank correlation coefficient. P-values were adjusted for multiple testing using the Benjamini-Hochberg procedure. Differential analysis was performed using the Mann-Whitney U test.